Cell choice for bioartificial livers
نویسندگان
چکیده
منابع مشابه
Concise Review: Liver Regenerative Medicine: From Hepatocyte Transplantation to Bioartificial Livers and Bioengineered Grafts.
Donor organ shortage is the main limitation to liver transplantation as a treatment for end-stage liver disease and acute liver failure. Liver regenerative medicine may in the future offer an alternative form of therapy for these diseases, be it through cell transplantation, bioartificial liver (BAL) devices, or bioengineered whole organ liver transplantation. All three strategies have shown pr...
متن کاملCryopreservation of Hepatocytes for Bioartificial Liver Devices
1 Introduction Supply of sufficient numbers of functional viable cells is one of the most controversial issues surrounding tissue and organ engineering. While use of autologous cells derived from the recipient patient is a feasible option for replacement of tissues such as cartilage, skin and bone, this is not a practical possibility for replacement of the function of organs such as liver. The ...
متن کاملHepatic progenitor cells from adult human livers for cell transplantation.
OBJECTIVE Liver regeneration is mainly based on cellular self-renewal including progenitor cells. Efforts have been made to harness this potential for cell transplantation, but shortage of hepatocytes and premature differentiated progenitor cells from extra-hepatic organs are limiting factors. Histological studies implied that resident cells in adult liver can proliferate, have bipotential char...
متن کاملCreation of Bioartificial Organs
Regenerative and reparatory medicine is one of the most attractive therapeutic options of the coming years, and the power to replace entire damaged organic structures or organs is, in our opinion, the most innovative possibility in this field. In relation to the creation of bioartificial organs in particular, hearts, lungs, livers, kidneys, ovaries, intestines, pancreas and corneas have already...
متن کاملA preliminary study for constructing a bioartificial liver device with induced pluripotent stem cell-derived hepatocytes
BACKGROUND Bioartificial liver systems, designed to support patients with liver failure, are composed of bioreactors and functional hepatocytes. Immunological rejection of the embedded hepatocytes by the host immune system is a serious concern that crucially degrades the performance of the device. Induced pluripotent stem (iPS) cells are considered a desirable source for bioartificial liver sys...
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ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 2003
ISSN: 1880-1293,0022-9717
DOI: 10.2302/kjm.52.151